COPYRIGHT© 2018 吉林紫鑫药业股份有限公司
The internationalization of Chinese medicine has gradually gained a "good prescription"
In the past, with the continuous improvement of the top-level design of Chinese medicine development, China's traditional Chinese medicine industry has been cultivating in the fields of strengthening scientific research and innovation, formulating industry standards, and docking international rules. Exploring the scientific path of the development of traditional Chinese medicine, the internationalization of Chinese medicine is getting better.
Once "slow Lang" is now "emergency"
At the just-concluded "Thirteenth International Symposium on Collateral Diseases", a research report on the "China's 973 project based on the theory of choroidal theory of cardiovascular and cerebrovascular disease" was released, which confirmed once again that Chinese medicine is in the treatment of cardiovascular disease. The exact effect of the disease.
In this study, the project experts proved the clinical application value of TCM Tongluo drug in solving the world medical problem without reflow and perfusion injury after myocardial infarction through clinical research, showing the unique advantages of traditional Chinese medicine.
More and more Chinese medicines are getting rid of the impression of “slow Langzhong” and launching a general attack on critically ill diseases such as acute myocardial infarction. With its extraordinary curative effect, it has attracted the attention of the international medical community and has gradually become a “pioneer” for treating acute and difficult diseases.
For a long time, due to the development of Western medicine and the backwardness of the overall level of TCM emergency, the concept of “Traditional Chinese Medicine Treatment of Chronic Diseases and Western Medicine Treatment of Acute Diseases” has been deeply rooted in the hearts of the people, causing the position of Chinese medicine in the critical and emergency areas to shrink. In fact, it is not difficult to find out that the history of Chinese medicine development has a long history and rich experience in treating acute diseases. From the Eastern Han Dynasty Zhang Zhongjing's "Treatise on Febrile Diseases" to the Tang Dynasty Sun Sizhen's "Prepare for the Urgent Needs" and then the establishment of the theory of warm disease in the Ming and Qing Dynasties, TCM emergency medicine has already formed a relatively complete theoretical system, with rich critical illness treatment. Medical doctors have great potential for the treatment of critical illness.
"The reason why the efficacy of traditional Chinese medicine in critically ill areas has not been revealed," said Wu Yiling, an academician of the Chinese Academy of Engineering. "It is because of insufficient attention."
Some experts have analyzed that the development of Chinese medicine has been weak for nearly half a century. It is very important that the research object of Chinese medicine is wrong, focusing on the treatment of chronic diseases, while ignoring the advantages of traditional Chinese medicine - critical illness.
In recent years, Chinese medicine has continued to exert its strength in the field of acute and severe diseases, and has obtained extraordinary research results and clinical practice effects. The ability of traditional Chinese medicine to treat critically ill patients has regained the attention and recognition of the world medical community.
According to the White Paper on Chinese Medicine published in 2016, Chinese medicine has played an important role in the prevention and treatment of major epidemics and medical emergencies in public emergencies, in addition to contributing to the prevention and treatment of common diseases, frequently-occurring diseases and incurable diseases. . The efficacy of traditional Chinese medicine and integrated traditional Chinese and Western medicine in the treatment of infectious atypical pneumonia has been affirmed by the World Health Organization. Chinese medicine treatment of influenza A H1N1 has achieved good results, and the results have attracted the attention of the international community. At the same time, Chinese medicine has played a unique role in the prevention and treatment of infectious diseases such as AIDS, hand, foot and mouth disease, human infection with H7N9 avian influenza, and the Wenchuan Earthquake in Sichuan and the Zhouqu Extra Large Debris Flow in Gansu.
In 2003, Chinese medicine treatment of SARS has achieved the use of pure Chinese medicine to cure SARS. Traditional Chinese medicine has become an important force in the fight against SARS. In 2013, when the H7N9 avian influenza virus was raging, the provinces once again raised the Chinese medicine response strategy to an important position. The H7N9 Chinese medicine prevention and treatment program was successively introduced, and the relevant treatment methods showed good clinical efficacy. Once again, people are made aware that the "Langzhong" treatment of acute illness that is good at working slowly is also a "connoisseur."
The relevant innovative research results of the treatment of acute and severe diseases with integrated Chinese and Western medicine have also been internationally recognized. Wang Zhenyi, an academician of the Chinese Academy of Engineering, and Chen Yu, a member of the Chinese Academy of Sciences, have significantly improved the efficacy of traditional Chinese medicine arsenic and western medicine in the treatment of acute promyelocytic leukemia, and won the 7th St. Gilgi Cancer Research Innovation Achievement Award. The innovative research and good results of traditional Chinese medicine in treating critically ill patients have made the world see the "energy" of traditional Chinese medicine, and gradually improve the embarrassing situation of traditional Chinese medicine in the Western countries "health products", "supplementary, alternative medicine" and "placebo". Helping to enter the international market as a "pharmaceutical".
The world needs Chinese medicine to go out
In recent years, the state has paid unprecedented attention to the development of Chinese medicine, and has continuously increased its investment in Chinese medicine research and the support of the Chinese medicine industry. The development of Chinese medicine has been fruitful, “flowering inside the wall, fragrance inside and outside”, Chinese medicine in The world’s influence has been widely improved.
"Chinese medicine goes to the world, the premise is because the world needs Chinese medicine." Zhong Nanshan, an academician of the Chinese Academy of Engineering, said that with the continuous improvement of the scientific research level of Chinese medicine and the clinical research results, modern medicine is also welcoming Chinese medicine with a more open attitude.
According to Zhang Boli, academician of the Chinese Academy of Engineering and president of Tianjin University of Traditional Chinese Medicine, at present, Chinese medicine has spread to 183 countries and regions. Currently, 103 member states have approved the use of acupuncture, 29 of which have established traditional medicine laws and regulations, and 18 will have acupuncture. Incorporate into the medical insurance system. Traditional Chinese medicine has also gradually entered the international medical system and has been registered in the form of medicines in Russia, Cuba, Vietnam, Singapore and the United Arab Emirates. Traditional Chinese medicine has become an important part of China's health and economic cooperation with ASEAN, EU, Africa, Central and Eastern Europe and other regions and organizations, and has become an important part of humanities exchanges between China and the rest of the world.
According to the World Health Organization, 4 billion people worldwide use Chinese herbal medicine to treat diseases, accounting for 40% of the world's total population. At present, the world traditional medical treatment market reaches 60 billion US dollars every year, and it is still growing. In 2015, the main business income of enterprises above designated size in China's traditional Chinese medicine industry exceeded 780 billion yuan, accounting for nearly one-third of the main business income of enterprises above designated size in China's pharmaceutical industry, and the import and export volume of Chinese medicines reached 4.8 billion US dollars. As a huge economic resource with great potential, Chinese medicine has made positive contributions to promoting the development of the health industry.
At present, the Chinese medicine market is still a blue ocean, which has great potential and needs further development. Not only in China, the developed countries such as the United States, the United Kingdom, Japan and South Korea are also actively carrying out research on Chinese medicine, laying out research and development and production of Chinese medicine, and have achieved corresponding results.
Researchers at Yale University extracted the active ingredients of four plants (peony, scutellaria, licorice, jujube, etc.) from the traditional Chinese medicine, and recombined to produce a stable anticancer drug. It has been proved by clinical practice that the drug has an adjuvant treatment effect on rectal cancer and can enhance the efficacy of various anticancer drugs. A Japanese study also showed that Astragalus has an anti-proliferative effect on myeloma cells.
In Japan, many Chinese herbal medicine companies have established their own Chinese research institutions and Chinese herbal medicine production bases. South Korea has also established a specialized research institute for Korean medicine. In Europe, the United Kingdom, Italy and other countries, there are already companies based on Chinese herbal medicine, research and experimentation of traditional Chinese medicine treatment of cancer and diabetes.
China has also taken a new step in the field of Chinese medicine research. According to the "13th Five-Year Plan for the Development of Traditional Chinese Medicine", during the 12th Five-Year Plan period, China established a clinical research system with 16 national TCM clinical research bases as the key platform, and the clinical research network for prevention and treatment of infectious diseases and chronic diseases by Chinese medicine has been improved. A total of 45 Chinese medicine achievements have been awarded national science and technology awards, and scientific research results have been transformed into clinical diagnosis and treatment standards, key technologies and a number of new Chinese medicines with independent intellectual property rights, which have achieved significant social and economic benefits.
To speak the world language, we must also talk about Chinese medicine language.
In fact, the internationalization of Chinese medicine is not a smooth one, but a difficult one. Traditional Chinese medicine and Western medicine are different in terms of origin, structure and concept. They are self-contained and inevitably subject to doubt and hindrance when they go abroad. In addition, compared with Western modern medicine, traditional Chinese medicine treatment will take different methods in time, from person to person and from disease to disease, and the curative effect is also uncertain. This is very different from the standardized production and treatment methods required by modern medicine. Problems such as lack of standards, unclear composition, unclear mechanism of action, and unstable drug effects restrict the internationalization of Chinese medicine.
Academician Zhong Nanshan said: "Chinese medicine wants to be recognized internationally to speak the world language." Chinese medicine is widely accepted by the world and relies on the affirmation of the efficacy of modern medicine. The key link is the internationalization of Chinese medicine standards and the study of Chinese medicine. The scientific nature of the verification method, "Chinese language internationalization must speak the world language means that Chinese medicine must be in line with international standards from research to production, in line with international standards."
In response to these key points, since last year, the relevant state departments have promulgated the "Thirteen Five-Year Plan for the Development of Traditional Chinese Medicine", "Strategic Outline of Chinese Medicine Development Strategy (2016-2030)", "Chinese Medicine Law" and "Chinese Medicine for Traditional Chinese Medicine" White Paper Such documents and laws and regulations provide guidance and guarantee for promoting the development and internationalization of Chinese medicine innovation from the top-level design.
At the specific operational level, Zhang Boli, an academician of the Chinese Academy of Engineering, said: "The internationalization of Chinese medicine needs to be supported by science and technology and guided by standards. First of all, we are required to cultivate the 'internal strength' of traditional Chinese medicine, and to do the work of Chinese medicine research and standard setting. Do a good job to ensure that Chinese medicine can be effective, safe and of controllable quality when it goes abroad."
Academician Zhang Boli introduced that in 2014, China launched the “National Medicine Safety Testing Technology and Standard Platform” project for the creation of major national new drugs. The project will solve the problems of quality control and safety of Chinese medicines by establishing endogenous and exogenous toxic and harmful ingredients detection methods and limit standards. At present, standard test methods for dyeing and weight gain of Chinese herbal medicines have been established, as well as hundreds of Chinese herbal medicine toxic components and pesticide residue limit standards. Among them, 50 Chinese medicine international recommendation standards, 20 kinds of entry into the US Pharmacopoeia review procedures, 10 Chinese medicine standards into the United States Pharmacopoeia.
The internationalization of Chinese medicine requires Chinese medicine products with controllable and stable quality. In view of the quality difference and shoddy phenomenon in the Chinese herbal medicine market, China promoted the research and promotion of Chinese herbal medicine cultivation and quality control technology, carried out many national surveys of Chinese medicine resources, and formed several drafts of industry norms and standards, and formulated The first ISO standard for Chinese medicine - the international standard for ginseng seed seedlings.
In the scientific research of traditional Chinese medicine, in recent years, China's traditional Chinese medicine industry has also actively integrated with the international community, and has changed from relying on experience to relying on clinical research in proof of efficacy. The modern medical research method represented by evidence-based medicine has also been widely used and used in the field of Chinese medicine research.
Academician Zhang Boli said that the use of evidence-based medical research methods has made Chinese traditional Chinese medicine research results better and faster accepted by foreign countries. According to reports, at present, there are 5 kinds of Chinese medicines in China through the US FDA Phase II clinical trials, and 4 kinds of registration studies in the EU.
Chinese medicine goes to the world, which requires both the world language and the characteristic language of Chinese medicine.
From the past unilateral drugs, to the efficacy of the compound drugs, it has been further accepted internationally. In addition to the "internal strength" of Chinese medicine, the international acceptance has also quietly changed. Academician Wu Yiling said: "From the experience of Chinese medicine participating in the second phase clinical trial of the US FDA, the evaluation mechanism has changed its focus on the mechanism and composition of the past, and now pays attention to curative effect. The world's views and requirements on Chinese medicine have also changed."
"The stone of other mountains can be used to attack jade, and the stones of both sides can bridge," said Academician Zhang Boli. "The road to internationalization of Chinese medicine is becoming wider and wider, and it is necessary for Chinese and Western medicine to communicate with each other in a more tolerant and open manner. improvement."